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KMID : 1161520090130020133
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Animal Cells and Systems
2009 Volume.13 No. 2 p.133 ~ p.139
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Characterization of angiogenesis inhibitor effect of green tea seed extract
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Hwang Jae-Ho
Lee Sung-Hoon
Rha Sung-Ju
Yoon Ho-Seop
Shin Jin-Hyuk
Lee Jin-Hee
Seo Myeong-Jin
Kang Kyeong-Wan
Han Kyeong-Ho
Kim Yong-Joo
Kho Kang-Hee
Kim Seon-Jae
Shin Tai-Sun
Oh Myung-Joo
Oh Suk-Jung
Seo Hyo-Jin
Kim Jong-Deog
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Abstract
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Green tea seed was extracted with absolute ethanol, and the green tea seed extract (GTSE) was subjected to assays for toxicity, antioxidant ability, angiogenesis inhibitory effects and cell adhesion, as well as western blotting, and an in vivo experiment against 4 high?ranking adult cancers in Korea. Our series of experimental data demonstrated that GTSE has an antioxidant ability superior to that of EGCG in the green tea leaf, and also exhibits a profound high tumor growth inhibitory activity on a variety of cancer cell lines, as well as nude mice infected with cancer cells. GTSE was identified as a natural anticancer compound showing excellent angiogenesis inhibition and cancer cell suppression abilities. Our preliminary observations also indicate that GTSE may be another potential source of natural dietary antioxidants and also may be applicable as a novel natural anticancer agent.
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KEYWORD
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green tea seed extract, anti-cancer, anti-angio-genesis, western blotting, in vivo animal experiment
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